A Pimple Cream that Actually Works: Insider Tips

What is the relationship between our body and these microorganisms? What do they do for our body?

Competition between or within microbial species can inadvertently provide beneficial effects for the human host. For example, Staphylococcus epidermidis colonizes the human body through sensing the human innate immune system and, in response, up regulates protective virulence factor proteases against endogenous antimicrobial peptide. Bacteria produce peptide toxins and free fatty acids that deter other potentially pathogenic organisms, such as Staphylococcus aureus and S. pyogenes, from inhabiting the skin. Corynebacterium jeikeium produces bacteriocin-like antimicrobial compounds and scavenges for nutrients, which prevents colonization by other competing species. C. jeikeium also produces superoxide dismutase, which protects the bacteria from superoxide radicals and may concurrently prevent oxidative damage to surrounding skin tissue. 

How do microbiomes form? 

It forms at birth and changes as we age. For infants by natural delivery, vaginal microorganisms such as Lactobacillus, Prevotella, and Sneathia dominate their skin. On the other hand, those delivered by cesarean section have Staphylococcus, Corynebacterium, and Propionibacterium microorganisms, which resembles the composition of adult skin.

Where are microbiome present in our bodies?

Different microbiomes are present in different locations of our body – based on the skin type of the location. The skin contains three major ecologic environments: dry (eg, forearm), moist (eg, axilla), and sebaceous (eg, scalp). Species diversity is the greatest in dry environments and the least in sebaceous. The types of organisms found in each site are suitable to thrive in that environment. Staphylococcus and Corynebacterium colonize in moist areas that have occlusion, because they prefer high humidity habitats, whereas Propionibacterium, a type of lipophilic bacteria, tends to colonize sebaceous areas. Microbiomes in each area can differ greatly during different life stages; for example, during puberty, there is an increased level of lipophilic bacteria levels due to an increase in sebum production compared with the adult state. Inter-individual differences are due to secondary factors and are attributable to environment, occupation, diet, or hygiene habits.

How do microbiomes affect us? 

The skin microbiome plays a role in atopic dermatitis (AD), which is a chronic inflammatory skin disorder. The genetic origin of AD is related to skin barrier function abnormalities. A child’s skin microbiome positively influences immune system development away from allergic over sensitization. Poor development or changes in the balance of the microbiome and the host’s cutaneous immune response leads children to become susceptible to a multitude of immune conditions, such as atopic dermatitis, which may lead to frequent secondary skin infections. 

Recent studies indicate a strong association between worsening disease severity and lower skin bacterial diversity. Traditional AD treatment with anti-inflammatory and antimicrobial medications has been linked to greater microbial diversity, specifically increases in the populations of Streptococcus, Corynebacterium, and Propionibacterium. 

What skin conditions do the microbiome affect?

Additionally, microbiome also plays a role in the pathogenesis of rosacea, which associates with Helicobacter pylori, S epidermidis, Chlamydia pneumonia, Bacillus olenorium, and Demodex mite. Rosacea is a chronic inflammatory condition of the blood vessels and pilosebaceous units of the face that commonly presents with flushing, blushing, and sensitive skin.

The microbiome also plays a role in seborrheic dermatitis, which we also know as dandruff, associated with the Malassezia yeasts. It is a chronic hyperproliferative inflammatory condition, typically resulting in a red and flaky appearance of the scalp, sebaceous areas of the face and sometimes chest. 

How the blemish spot pimple cream actually works?
The role of skin microbiome in acne

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units and occurs in sebaceous areas of the face, neck, chest, and back. In adolescence and adulthood, sebaceous areas are colonized primarily by the lipophilic Propionibacterium. Propionibacterium hydrolyzes triglycerides in sebum to produce free fatty acids, which acidify and weaken the skin, exacerbating acne vulgaris. However, Propionibacterium is not the only causal factor of acne. Sebaceous areas are very low in bacteria diversity, and it can be postulated that changes in sebum production or its composition can help foster the growth of different strains of P. acnes.

How this pimple cream works to treat the acne microbiome?

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