2% Niacinamide Dark Spot Lightening Cream

$58.85 (w/gst)


[VOLUME] 3ml


2% Niacinamide

Treats pigmentation including
Under eye dark circles
Solar Lentigo (sun spots)
Post-inflammation hyperpigmentation from Dermatitis
Acne scars

This 2% Niacinamide prescriptive cream is custom compounded by Dr.TWL Pharmacy as an effective cream for dark spot lightening. If you are searching for a dark spot corrector to remove your skin pigmentation, niacinamide is a proven active ingredient that can help to remove skin pigmentation with minimal skin irritation.

*Disclaimer: results vary between individuals, can be used as adjunct treatment in consultation with a dermatologist

Earn 55.00 Reward Points
$55.00 SGD


Targets mechanisms in pigmentation and dark spot formation
      Prevents transfer of pigment within the skin
      Inhibits melanin formation

Treats acne scarring, erythema, post-inflammation hyperpigmentation
      Potent antioxidant
      Combats oxidative stress

Contains LARECEA™ Extract accelerates collagen formation, for skin regeneration and potent oligopeptides for lifting and repair.

Note: Unscented, fragrance-free, may exhibit natural scent of active ingredients.


What is niacinamide?
Niacinamide, also known as nicotinamide, is a specific form of vitamin B3 (an amide) and a  powerhouse ingredient for brightening and hydration. It is not produced by the body, which means that if we want to reap its benefits, it should be topically applied to the skin. 

How does pigmentation, or dark spots, form?
There are several types of hyperpigmentation or dark spots, usually in the form of solar lentigo (sun spots) that is related to excess sun exposure over time, melasma caused by hormonal changes, and post inflammatory hyperpigmentation caused by inflammation of the skin, most commonly, acne. 

A common cause of pigmentation is excess production of melanin – the pigment that gives skin its color. Melanin is produced by melanocytes and is then transferred to keratinocytes (skin cells) by melanosomes. 

Does it work? What are its benefits?
Niacinamide’s main benefit is that it helps to lighten pigmentation.The results from two experiments in the presence and absence of niacinamide showed that niacinamide downregulated the amount of melanosomes (pigment carrying cells) transferred within the skin by approximately 35–68% (1). In clinical studies niacinamide significantly decreased hyperpigmentation and increased skin lightness after 4 weeks of use. 

Apart from being a powerful skin lightening agent, niacinamide also has anti-inflammatory properties, is a powerful antioxidant, improves aging facial skin, moisturize dry atopic skin, and helps to protect the skin from immunosuppressive effects of the sun’s UV rays (2) – making it an effective anti-aging ingredient (3). 

Are there any side effects?
Unlike hydroquinone, a popular skin lightening agent that commonly causes skin irritation,  niacinamide does not cause skin irritation at low concentrations (1-2%). 


Work a pea-sized amount morning and evening to targeted area with ring finger.

Monitor your clinical response with the Hydration Skin Analyzer – Skin Barrier Biosensor


(1) Hakozaki, T., Minwalla, L., Zhuang, J., Chhoa, M., Matsubara, A., Miyamoto, K., Greatens, A., Hillebrand, G. G., Bissett, D. L., & Boissy, R. E. (2002). The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. The British journal of dermatology, 147(1), 20–31. doi:10.1046/j.1365-2133.2002.04834.x

(2) Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. doi:10.1155/2011/379173

(3) Chiu PC, Chan CC, Lin HM, Chiu HC. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 2007;6(4):243-249. doi:10.1111/j.1473-2165.2007.00342.x